P2B235: Mean Hematocrit Values, Disease Severity, and Discharge Status of Undernourished versus Well-nourished Children with Dengue Infection in a Tertiary Government Hospital

Background: Studies comparing hematocrit values, disease severity, and discharge status between well-nourished and undernourished pediatric dengue patients are limited

Methods: A retrospective cohort study involving 114 pediatric dengue patients, with comparison groups of well-nourished and undernourished children matched according to age, phase of illness, and sex was done. Main outcomes measured were mean hematocrit values, disease severity, and and discharge status.

Results: There was a significantly lower mean pre-resuscitation hematocrit in the wasted (M=39.67%, SD= 3.78) compared to the well-nourished group (M=43.86%, SD 4.72), p=0.006, among children >6 to 12 years old in the febrile phase. There were no significant differences in disease severity and discharge status between wasted and well-nourished children. In those >2 to 6 years old in the febrile phase, the severely wasted had significantly higher pre-resuscitation hematocrit (M=43.28%, SD=4.77) compared to well-nourished children (M=39.11%, SD=5.34), p=0.041. More severe dengue, worse discharge status and an earlier time to demise was seen among severely wasted children.

Conclusion: Wasted participants had significantly lower mean hematocrit values with no difference in disease severity and discharge status when compared to well-nourished participants. Severely wasted children had significantly high hematocrit values, severe dengue, and worse discharge status.